Rabies - Bulletin - Europe

WHO Collaborating Centre for Rabies Surveillance & Research

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Thu, 01/27/2011 - 19:31

What is rabies?

Rabies (Lyssa) is one of the oldest known zoonotic diseases; an animal disease transmissible to humans.

Thu, 01/27/2011 - 18:57

Transmission and pathogenesis

In most cases the disease is transmitted via the bite of rabid animals which shed infectious virus with their saliva.

Thu, 01/27/2011 - 18:56

Classification

Rabies is caused by negative strand RNA-viruses belonging to the genus Lyssavirus, family Rhabdoviridae of the order Mononegavirales.

Thu, 01/27/2011 - 18:54

Diagnosis of rabies in animals

Even with symptoms quite characteristic for rabies, like changes in behaviour or difficulties in swallowing the clinical examination cannot rule out rabies nor confirm the diagnosis.

Thu, 01/27/2011 - 18:26

Virus structure

The RNA genome of Lyssaviruses is 12 kilobases long, non-segmented and of negative polarity encoding five viral proteins (3´ to 5´): nucleoprotein N, phosphoprotein P, matrix protein M, glycoprotein G and polymerase L.

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Rabies Information System of the WHO Collaboration Centre for Rabies Surveillance and Research.

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