Rabies - Bulletin - Europe

WHO Collaborating Centre for Rabies Surveillance & Research

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In most cases the disease is transmitted via the bite of rabid animals which shed infectious virus with their saliva. The virus enters the body through transdermal inoculation (i.e. wounds) or direct contact of infectious material (i.e. saliva, cerebrospinal liquid, nerve tissue) to mucous membranes or skin lesions. The virus can not penetrate intact skin.

Transmission

The RNA genome of Lyssaviruses is 12 kilobases long, non-segmented and of negative polarity encoding five viral proteins (3´ to 5´): nucleoprotein N, phosphoprotein P, matrix protein M, glycoprotein G and polymerase L.

Rabies is caused by negative strand RNA-viruses belonging to the genus Lyssavirus, family Rhabdoviridae of the order Mononegavirales.

Rabies (Lyssa) is one of the oldest known zoonotic diseases; an animal disease transmissible to humans.

Rabies and Rabies Vaccines

Editor(s): Ertl, Hildegund C. J. (Ed.)

ISBN 9783030210847

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