Rabies - Bulletin - Europe

Rabies Information System of the WHO

Classification

Rabies is caused by negative strand RNA-viruses belonging to the genus Lyssavirus, family Rhabdoviridae of the order Mononegavirales. According to the International Committee on Taxonomy of Viruses (ICTV) the genus Lyssavirus is delineated into different virus species based on demarcation criteria such as genetic distance and antigenic patterns in reactions with panels of antinucleocapsid monoclonal antibodies. This demarcation is further supported by geographic distribution and host range (see table).

Lyssavirus species segregate into two phylogroups. Phylogroup 1 includes Rabies lyssavirus, Duvenhage lyssavirus, European bat lyssaviruses, type 1 and 2, Bokeloh bat lyssavirus, and Australian bat lyssavirus. Also, Aravan lyssavirus, Khujand lyssavirus, and Irkut lyssavirus are members of phylogroup 1. Phylogroup 2 includes Lagos bat lyssavirus, Mokola lyssavirus, and Shimoni bat lyssavirus. There is a significant serological neutralization within phylogroups, but very limited crossneutralization has been detected between phylogroups. West Caucasian bat lyssavirus, Ikoma lyssavirus and Lleida bat lyssavirus may form independent phylogroups.

Rabies virus (RABV), the prototype lyssavirus, is responsible for the vast majority of all human rabies cases. However, it can be assumed that all lyssaviruses can cause indistinguishable fatal encephalitis both in humans and other mammals.

Interestingly, bats are primary or sole reservoir hosts for all lyssaviruses except MOKV and IKOV (for which the reservoir species have not been clearly identified as of yet).

Current diversity and taxonomy of lyssaviruses

Approved Species (ICTV)a

Virus

Potential vector(s)/reservoirs

Distribution

Rabies lyssavirus

Rabies virus (RABV)

Carnivores (worldwide); bats
(Americas) 

Worldwide
(except several islands)

Lagos bat lyssavirus

Lagos bat virus (LBV)

Frugivorous bats (Megachiroptera)

Africa

Mokola lyssavirus

Mokola virus(MOKV)

?

Sub-Saharan Africa

Duvenhage lyssavirus

Duvenhage virus (DUVV)

Insectivorous bats

Southern Africa

European bat 1 lyssavirus

European bat lyssavirus 1 (EBLV-1)

Insectivorous bats
(Eptesicus serotinus)

Europe

European bat 2 lyssavirus

European bat lyssavirus 2 (EBLV-2)

Insectivorous bats
(Myotis daubentonii, M. dasycneme)

Europe

Australian bat lyssavirus

Australian bat lyssavirus (ABLV)

Frugivorous/insectivorous bats
(Megachiroptera/Microchiroptera

Australia

Aravan lyssavirus

Aravan virus (ARAV)

Insectivorous bats

(Myotis blythi)

Central Asia

Khujand lyssavirus

Khujand virus (KHUV)

Insectivorous bats

(Myotis mystacinus)

Central Asia

Irkut lyssavirus

Irkut avirus (IRKV)

Insectivorous bats

(Murina leucogaster)

East Siberia

West Caucasian bat lyssavirus

West Caucasian bat virus (WCBV)

Insectivorous bats

(Miniopterus schreibersi)

Caucasian region

Shimoni bat lyssavirus

Shimoni bat virus (SHBV)

Hipposideros commersoni

East Africa

Bokeloh bat lyssavirus

Bokeloh bat lyssavirus (BBLV)

Insectivorous bats

Myotis nattereri

Europe

Ikoma lyssavirus

Ikoma virus (IKOV)

? (isolated from Civettictis civetta)

Africa

Gannoruwa bat lyssavirus

Gannoruwa bat lyssavirus (GBLV)

Isolated from Pteropus giganteus

Asia

Lleida bat lyssavirus

Lleida bat lyssavirus (LLEBV)

Insectivorous bats

(Miniopterus schreibersi)

Europe

(Spain)

 a ICTV = International Committee on Taxonomy of Viruses (www.ictvonline.org/)

Back to Top